679353

Knex 78780 - Education DNA Replication Teachers Guide Manual

43
Zoom out
Zoom in
Previous page
1/46
Next page
41
Objectives
Students will be able to:
1. Recognize basic types of errors in DNA replication.
2. Predict altered gene products resulting from errors in replication.
3. Understand how and when errors in replication may lead to permanent mutations.
mAteriAls
Each student group should have the following:
• 1K’NEX DNA, Replication and Transcription kit with building instructions booklet
• Studentjournals(1perstudent)
Prebuild
• EachstudentgroupshouldbeginwithonereplicatedDNAladderthathasbeencoiledintoadouble
helix. The double helix should have one parent strand made with gray Connectors for deoxyribose
sugars and one daughter strand made with yellow Connectors for deoxyribose sugars, as described
in Lesson 3 and as shown on pages 10 – 17 of the K’NEX DNA, Replication and Transcription
building instructions booklet.
• Studentgroupsshouldbeencouragedtousedifferent,randombase-pairsequences.
PreliminAry Activity: Simulating a Mutation Event
• StudentsshouldrecordthebasesequenceofboththeparentanddaughterstrandsoftheirDNA
molecule in their journals. A complementary strand of mRNA should be built as described in
Lesson 4 using the daughter strand as the template. (Reminder: this means that the parent strand
is the coding strand.) The mRNA sequence should also be recorded in the students’ journals and
the corresponding amino acid sequence should be determined and recorded.
• Instructstudentstomutatethedaughter strand of their double helical DNA molecule by using one
of three methods:
1. Substitution: Change the nitrogen-containing base in any one deoxyribonucleotide sub-unit on
the daughter strand. Any teal, black, white or silver rod may be exchanged for one of the three
remaining colors.
2. Deletion: Remove one deoxyribonucleotide sub-unit from any point on the daughter strand,
reconnecting the backbone by linking the remaining adjacent nucleotides.*
3. Insertion: Insert one additional deoxyribonucleotide sub-unit at any point in the backbone of
the daughter strand.*
* NOTE: Students will need to carefully stretch and bend the double-stranded DNA molecule to
accommodate the resulting unmatched nitrogen-containing base in the backbone on one side of
the molecule.
Students should now change the sequence of their mRNA molecule to represent the mutational event
just simulated and record the new sequence in their journals.
MODULE III: CODING, TRANSLATION, AND MUTATIONS
Acknowledgement: The graphic used in the title and as a design element throughout this Guide has been provided courtesy of the National Human
Genome Research Institute.
888-ABC-KNEX
Education
®
… 43 …


Need help? Post your question in this forum.

Forumrules


Report abuse

Libble takes abuse of its services very seriously. We're committed to dealing with such abuse according to the laws in your country of residence. When you submit a report, we'll investigate it and take the appropriate action. We'll get back to you only if we require additional details or have more information to share.

Product:

For example, Anti-Semitic content, racist content, or material that could result in a violent physical act.

For example, a credit card number, a personal identification number, or an unlisted home address. Note that email addresses and full names are not considered private information.

Forumrules

To achieve meaningful questions, we apply the following rules:

Register

Register getting emails for Knex 78780 - Education DNA Replication Teachers Guide at:


You will receive an email to register for one or both of the options.


Get your user manual by e-mail

Enter your email address to receive the manual of Knex 78780 - Education DNA Replication Teachers Guide in the language / languages: All languages as an attachment in your email.

The manual is 4,73 mb in size.

 

You will receive the manual in your email within minutes. If you have not received an email, then probably have entered the wrong email address or your mailbox is too full. In addition, it may be that your ISP may have a maximum size for emails to receive.

The manual is sent by email. Check your email

If you have not received an email with the manual within fifteen minutes, it may be that you have a entered a wrong email address or that your ISP has set a maximum size to receive email that is smaller than the size of the manual.

The email address you have provided is not correct.

Please check the email address and correct it.

Your question is posted on this page

Would you like to receive an email when new answers and questions are posted? Please enter your email address.



Info